background: polycystic ovary syndrome (pcos) is one of the most common endocrine women’s disorders in reproductive age. hyperandrogenism has a critical role in the etiology of pcos and it can cause fault in steroidogenesis process. during steroidogenesis, steroidogenic acute regulatory protein (star) seems to increase the delivery of cholesterol through mitochondrial membrane. therefore, polymo...

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, affecting 5-10% of reproductive aged women. High levels of androgen hormone can be accounted as the most important symptoms in PCOS. Androgen is the precursor of steroid biosynthesis in ovary. The transport of cholesterol to the inner mitochondrial membrane through StAR protein is also necessary for andr...

testosterone is believed to play a significant role in spermatogenesis, but its contribution to the process of spermatogenesis is not completely understood. given that extracellular matrix (ecm) facilitates differentiation of spermatogonial stem cells (sscs) during culture, the present study was conducted to elucidate whether testosterone contribute to the permissive effect of ecm on sscs diffe...

Testosterone is believed to play a significant role in spermatogenesis, but its contribution to the process of spermatogenesis is not completely understood. Given that extracellular matrix (ECM) facilitates differentiation of spermatogonial stem cells (SSCs) during culture, the present study was conducted to elucidate whether testosterone contribute to the permissive effect of ECM on SSCs diffe...

star identification is one of the most important stages in attitude determination with star trackers. this can be performed using matching algorithms between observed stars and a master star catalogue. the main challenge in this approach is to provide a fast and reliable identification algorithm that is sufficiently robust in different pointing views of the star tracker optical system in the sp...

Organophosphate pesticides are considered as endocrine disruptors that interfere with reproductive functions. The corpus luteum (CL) is a transient endocrine gland that produces progesterone, a crucial hormone for a successful beginning and maintenance of pregnancy. Steroidogenic acute regulatory protein (StAR) facilitates the rate-limiting transfer of cholesterol from the outer mitochondrial m...

Organophosphate pesticides are considered as endocrine disruptors that interfere with reproductive functions. The corpus luteum (CL) is a transient endocrine gland that produces progesterone, a crucial hormone for a successful beginning and maintenance of pregnancy. Steroidogenic acute regulatory protein (StAR) facilitates the rate-limiting transfer of cholesterol from the outer mitochondrial m...

Recent studies suggested an involvement of thromboxane A2 in cyclooxygenase-2-dependent inhibition of steroidogenic acute regulatory (StAR) gene expression. The present study further investigated the role of thromboxane A2 receptor in StAR gene expression and steroidogenesis in testicular Leydig cells. The thromboxane A2 receptor was detected in several Leydig cell lines. Blocking thromboxane A...